Neurobiology & Anatomy; Centers for Neuroscience
Ph.D., Anatomy, Michigan State University
NIH Individual Postdoctoral Fellow, Departments of Internal Medicine and Pharmacology, University of Texas Health Science Center at Dallas
The research in my lab focuses on neuroanatomical organization and embryological development of airway innervation, examining interconnections between airway neurons and airway structures (smooth muscle, blood vessels, glands, epithelium), and on determining neuronal responses to inhaled irritants. Different types of nerves including sensory, sympathetic, parasympathetic, and nonadrenergic/noncholinergic supply the trachea and bronchi. Released neurotransmitters mediate bronchial and vascular smooth muscle tone, mucous secretion, coughing, and breathing patterns in normal conditions and produce defensive responses after inhalation of irritant substances. Airway nerves may also contribute to lung diseases like asthma, chronic cough, and chronic obstructive pulmonary disease (COPD). Although there is considerable information regarding the actions of neurotransmitters, such as acetylcholine, norepinephrine, vasoactive intestinal peptide, substance P and nitric oxide, the mechanisms through which airway nerves contribute to asthma and other airway diseases is not clear. Regulatory molecules like neurotrophins may be critical in altering neurotransmitter expression and airway innervation leading to asthma and airway inflammation. Combinations of immunocytochemical, molecular biological, neurophysiological and pharmacological approaches are used to investigate pulmonary neural responses to inhaled irritants such as ozone, a photochemical environmental pollutant, and toluene diisocyanate, a catalyst associated with occupational asthma used in manufacturing polymers.
- Wu ZX, Hunter DD, Batchelor TP, Dey RD. Side-stream tobacco smoke-induced airway hyperresponsiveness in early postnatal period is involved nerve growth factor. Respir Physiol Neurobiol (2016) 223:1-8. PMID: 26638730
- Barker JS, Wu Z, Hunter DD, Dey RD. Ozone exposure initiates a sequential signaling cascade in airways involving interleukin-1beta release, nerve growth factor secretion, and substance P upregulation. J Toxicol Environ Health A (2015) 78(6): 397-407.PMCID: PMC4491938
- Goravanahally MP, Hubbs AF, Fedan JS, Kashon ML, Battelli LA, Mercer RR, Goldsmith WT, Jackson MC, Cumpston A, Frazer DG, Dey RD. Diacetyl increases sensory innervation and substance P production in rat trachea. Toxicol Pathol (2014) 42(3): 582-90. PMCID: PMC4637165
- Goravanahally MP, Hubbs AF, Fedan JS, Kashon ML, Battelli LA, Mercer RR, Goldsmith WT, Jackson MC, Cumpston A, Frazer DG, Dey RD. Diacetyl Increases Sensory Innervation and Substance P Production in Rat Trachea. Toxicol Pathol (2013 Jul) Epub ahead of print.
- Wu ZX, Benders KB, Hunter DD, Dey RD. Early postnatal exposure of mice to side-steam tobacco smoke increases neuropeptide Y in lung. Am J Physiol Lung Cell Mol Physiol, (2012 Jan 1) 302(1):L152-9.
- Zellner LC, Brundage KM, Hunter DD, Dey RD. Early Postnatal Ozone Exposure Alters Rad Nodose and Jugular Sensory Neuron Development. Toxicol Environ Chem, (2011 Jan 1) 93(10):2055-2071.
- Hunter DD, Carrell-Jacks LA, Batchelor TP, Dey RD. Role of nerve growth factor in ozone-induced neural responses in early postnatal airway development. Am J Respir Cell Mol Biol, (2011 Aug) 45(2):359-65.
- Hunter DD, Wu Z, Dey RD. Sensory Neural Responses to Ozone Exposure during Early Postnatal Development in Rat Airways. Am J Respir Cell Mol Biol (2010).
Wu ZX, Hunter DD, Kish VL, Benders KM, Batchelor TP,
Prenatal and early, but not late, postnatal exposure of mice to sidestream
tobacco smoke increases airway hyperresponsiveness later in life.
Environ Health Perspect (2009), 117(9):1434-40.
Nadeem A, Ponnoth DS, Ansari HR, Batchelor TP,
Dey RD, Ledent C, Mustafa SJ.
A2A adenosine receptor deficiency leads to impaired tracheal relaxation via
NADPH oxidase pathway in allergic mice.
J Pharmacol Exp Ther. (2009), 330(1):99-108.
- Wu ZX, BarkerJS, Batchelor TP, Dey RD. Interleukin (IL)-1 regulates ozone-enhanced tracheal smooth muscle responsiveness by increasing substance P (SP) production in intrinsic airway neurons of ferret. Respir Physiol Neurobiol (2008), 164(3):300-11.