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Xuefang (Sophie) Ren, MD

Research Assistant Professor, Director of Experimental Stroke Core

 Xuefang Sophie Ren

304-581-1892

Department

Physiology and Pharmacology

Graduate Training

Ulm University, Germany  Dr. Med. in Science 
Fudan University, China  M.Sc. in Immunology

Fellowship

RWTH Aachen University, Germany, in Atherosclerosis
University of Wuerzburg, Germany, in Atherosclerosis 
Oregon Health & Science University, in Stroke & Immunology 
Louisiana State University Health Science Center, in Stroke & Stem cells  

Research Interests

Stroke is a human killer and a major cause of serious long-term disability. My research interests focus on understanding the pathophysiology of stroke including blood-brain barrier damage, neuronal death, peripheral inflammation, and long-term plasticity processes. In vivo, ex vivo, and in vitro models are integrated in my research toolbox. My long-term goal devotes to finding out the effective treatments for stroke. 

Research Topics

1.Stroke and Immunology 
2.Stroke and mitochondria 
3.Stroke and micoRNAs 
4.Brain repair and functional recovery after stroke

Collaborators

Dr. James Simpkins
Dr. Taura L Barr
Dr. Paul Chantler
Dr. Jamal Mustafa
Dr. Sergiy Yakovenko
Dr. Charles Rosen
Dr. Candice Brown\
Dr. Paul Lockman,
Dr. Mandal, Sabhrangsu

Publications

1. Doll DN, Hu H, Sun J, Lewis, SE,Simpkins JW, Ren X*. Mitochondrial Crisis in Cerebrovascular Endothelial Cells Opens the Blood-Brain Barrier. Stroke. 2015 46(6):1681-1689. PMID: 25922503.*Corresponding author.

2. Doll DN, Rellick SL, Barr TL, Ren X, Simpkins JW. Rapid mitochondrial dysfunction mediates TNF-alpha-induced neurotoxicity. J Neurochem. 2015 Feb;132(4):443-51. PMID: 25492727.

3. Cui L, Duchamp NS, Boston DJ, Ren X, Zhang X, Hu H, Zhao LR. NF-κB is involved in brain repair by stem cell factor and granulocyte-colony stimulating factor in chronic stroke. Exp Neurol. 2015, 263:17-27. PMID: 25281484. 

4. Ren X, Akiyoshi K, Grafe MR, Vandenbark AA, Hurn PD, Herson PS, Offner H. Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity. Metab Brain Dis. 2012, 27(1):7-15. PMID: 21989743. 
5. Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H. Programmed death-1 pathway limits CNS inflammation and neurologic deficits in murine experimental stroke. Stroke. 2011, 42(9):2578-2583. PMID: 21737801.
 
6. Ren X, Akiyoshi K, Dzienni S, Vandenbark AA, Herson PS, Hurn PD, Offner H. Regulatory B-cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci. 2011, 31(23):8556–8563. PMID: 21653859. 

7. Akiyoshi K, Dziennis S, Palmateer J, Ren X, Vandenbark AA, Offner H, Herson PS, Hurn PD. Recombinant T Cell Receptor Ligands improve outcome after experimental cerebral ischemia. Translational Stroke Research. 2011, 2:404-410. PMID: 21961027.

8. Dziennis S, Mader S, Akiyoshi K, Ren X, Ayala P, Burrows GG, Vandenbark AA, Herson PS, Hurn PD, Offner H. Therapy with Recombinant T cell Receptor Ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice. Metab Brain Dis. 2011, 26(2):123:133. PMID: 21472429. 

9. Ren X, Akiyoshi K, Vandenbark AA, Hurn PD, Offner H. CD4(+)FoxP3(+) regulatory T-cells in cerebral ischemic stroke. Metab Brain Dis. 2011, 26(1):87-90. PMID: 21082336. 

10. Ren X, Ye F, Jiang Z, Chu Y, Xiong S, Wang Y. Involvement of Cellular Death in TRAIL/DR5-Dependent Suppression Induced by CD4+CD25+ Regulatory T Cells. Cell Death and Differentiation, 2007, 14, 2076–2084. PMID: 17762882.