Dr. Rosen has led development on a novel mechanism for studying blast with a table top device. This device has allowed blast to be readily studied on both rats and mice. These studies have led to early identification of how mild TBI can result in behavioral changes, as well as possible biological mechansims by which this injury is occurring. Dr. Rosen has also developed and studied a model of ischemia in aged rodents that utilizes a selective placement of a thrombus with a microcatheter in the middle cerebral artery. He has been studying and has published on the use of this model to study the blood brain barrier, activation of the neuro-inflammatory cascade, as well as work on several potential neuroprotectants. He has extensive expertise on the use of rodent models of ischemia for studying the molecular mechanisms of ischemia. This model has been illustrative in demonstrating why certain agents have failed to translate from bench to bedside. It is hoped that the marriage of these expertise in two very different models of brain injury will allow for the identification of agents that will have a higher chance of success in translating to clinical utility Dr. Rosen and his collaborators have recently completed successful studies on the use of bryostatin as a neuroprotectant in our acute model of rodent ischemia. Identification of pharmaceuticals that may influence the brain response to TBI, such as manipulators of the ER stress pathway are under testing.
In addition to this Dr. Rosen is Professor and Chair of the Department of Neurological Surgery. Dr. Rosen has a very busy practice in neurovascular surgery as well as providing emergency neurosurgery services at four hospitals with a catchment area of over 1 million patients. He frequently provides care to patients with neurovascular disease, such as stroke and aneurysms, as well as manages traumatic brain injury. This unique combination of experiences allows Dr. Rosen to design and supervise clinically relevant experiments utilizing animal models with a focus on translation to clinical utility. As a practicing neurosurgeon, I have been treating TBI patients for nearly 20 years. There is huge unmet need for neuroprotection, and changing the way we manage both acute and chronic TBI. Studies proposed in this grant are critical early steps at identifying such potential tools.
- Lucke-Wold BP, Turner RC, Logsdon AF, Bailes JE, Huber JD, Rosen CL. Linking Traumatic Brain Injury to Chronic Traumatic Encephalopathy: Identification of Potential Mechanisms Leading to Neurofibrillary Tangle Development. J Neurotrauma (2014 Feb 5) [Epub ahead of print]
- Turner RC, VanGilder RL, Naser ZJ, Lucke-Wold BP, Bailes JE, Matsumoto RR, Huber JD, Rosen CL. Elucidating the Severity of Preclinical Traumatic Brain Injury Models: A Role for Functional Assessment? Neurosurgery (2014 Jan 19) [Epub ahead of print]
- Tan Z, Turner RC, Leon RL, Li X, Hongpaisan J, Zheng W, Logsdon AF, Naser ZJ, Alkon DL, Rosen CL, Huber JD. Bryostatin improves survival and reduces ischemic brain injury in aged rats after acute ischemic stroke. Stroke (2013 Dec) 44(12): 3490-7.
- Turner RC, Naser ZJ, Logsdon AF, DiPasquale KH, Jackson GJ, Robson MJ, Gettens RT Matsumoto RR, Huber JD, Rosen CL. Modeling clinically relevant blast parameters based on scaling principles procedures functional & histological deficits in rats. Exp Neurol (2013 Oct) 248: 520-9.
- VanGilder RL, Davidov DM, Stinehart KR, Huber JD, Turner RC, Wilson KS, Haney E, Davis SM, Chantler PD, Theeke L, Rosen CL, Crocco TJ, Gutmann L, Barr TL. C-reactive protein and long-term ischemic stroke prognosis. J Clin Neurosci (2013 Aug 23) pii:S0967-5868(13)00452-9.
- Turner RC, Lucke-Wold B, Lucke-Wold N, Elliott AS, Logsdon AF, Rosen CL, Huber JD. Neuroprotection for ischemic stroke: moving past shortcomings and identifying promising directions. Int J Mol Sci (2013 Jan) 14(1): 1890-917.
- Turner RC, Dodson SC, Rosen CL, Huber JD. The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success. J Neurosurg (2013 Jan 18) [Epub ahead of print].
- Lucke-Wold BP, Turner RC, Lucke-Wold AN, Rosen CL, Huber JD. Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke. Yale J Biol Med (2012 Dec) 85(4): 523-39.
- Turner RC, Naser ZJ, Bailes JE, Smith DW, Fisher JA, Rosen CL. Effect of slosh mitigation on histologic markers of traumatic brain injury: laboratory investigation. J Neurosurg (2012 Dec) 117(6): 1110-8.
- Turner RC, Seminerio MJ, Naser ZJ, Ford JN, Martin SJ, Matsumoto RR, Rosen CL, Huber JD. Effects of aging on behavioral assessment performance: implications for clinically relevant models of neurological disease. J Neurosurg (2012 Sep) 117(3): 629- 37.
- Leon RL, Li X, Huber JD, Rosen CL. Worsened outcome from middle cerebral artery occlusion in aged rats receiving 17Β-estradiol. Endocrinology (2012 Jul) 153(7): 3386- 93. • Popa-Wagner A, Buga AM, Turner RC, Rosen CL, Toescu E. Cerebrovascular disorders: role of aging. J Aging Res (2012) 2012:128146.
- VanGilder RL, Huber JD, Rosen CL, Barr TL. The transcriptome of cerebral ischemia. Brain Res Bull (2012 Jul) 88(4): 313-9.
- Rosen CL, Steinberg GK, DeMonte F, Delashaw JB Jr, Lewis SB, Shaffrey ME, Aziz K, Hantel J, Marciano FF. Results of the prospective, randomized, multicenter clinical trial evaluating a biosynthesized cellulose graft for repair of dural defects. Neurosurgery (2011 Nov) 69(5): 1093-103.
- Leon RL, Huber JD, Rosen CL. Potential age-dependent effects of estrogen on neural injury. Am J Pathol (2011 Jun) 178(6): 2450-60.
- Turner RC, Dodson SC, Rosen CL. Medical management of cerebellar abscess: a case report and review of the literature. WV Med J (2011 Mar-Apr) 107(2): 21-3.
- VanGilder RL, Rosen CL, Barr TL, Huber JD. Targeting the neurovascular unit for treatment of neurological disorders. Pharmacol Ther (2011 Jun) 130(3): 239-47.
- Sivak-Callcott JA, Diaz SR, Ducatman AM, Rosen CL, Nimbarte AD, Sedgeman JA. A Survey Study of Occupational Pain and Injury in Ophthalmic Plastic Surgeons. Ophthal Plast Reconstr Surg. (2011 Jan - Feb), 27(1):28-32.