Students in Dr. Visvanathan Ramamurthy’s lab recently had
two new papers accepted for publication, one of which was recommended by a
Faculty of 1000 member.
The paper entitled, “ARL3regulates trafficking of prenylated phototransduction proteins to the rod outersegment” (Wright ZC, et al), published in Human
Molecular Genetics (2016), was recommended by a F1000 member as being of
special significance in its field. In this study, Dr. Ramamurthy’s lab
generated transgenic mice expressing a dominant active form of ARL3 under a
rod-specific promoter, in order to determine the importance of ARL3 in rod
photoreceptor cells. Unexpectedly, this study revealed a novel role for ARL3 in
the migration of photoreceptor nuclei, and identified ARL3 as a key player in prenylated
protein trafficking in rod photoreceptor cells. This study also establishes the
potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms
of X-linked retinitis pigmentosa (XLRP).
The second paper, entitled, “Deficiency of Isoprenlycysteine CarboxylMethyltransferase (ICMT) leads to progressive loss of photoreceptor function” (Christiansen JR, et al), was published in The Journal of Neuroscience (2016). The findings of this study demonstrate that carboxyl methylation of isoprenylated proteins is crucial for maintenance of photoreceptor function, and that an absence of isoprenylcysteine methyltransferase-mediated protein methylation leads to progressive loss of vision.
For more information, please visit Dr. Ramamurthy’s webpage.