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Andrew Dacks, PhD

Assistant Professor

Studying invertebrate neurobiology and neuroethology, specifically modulation of neural circuitry and effects on behavior.

Affiliations

Biology; Blanchette Rockefeller Neurosciences Institute 

Graduate Training

The University of Arizona, PhD Graduate Interdisciplinary Program in Insect Science

Fellowship

Postdoctoral Research Associate, Division of Neurobiology, University of Arizona; Postdoctoral Excellence in Research and Teaching Fellow, Center for Insect Science, University of Arizona; Postdoctoral Fellow, Department of Neuroscience, Mount Sinai School of Medicine

Lab website:  www.dacksneuroscience.com

Research Interests

Modulation of Olfactory Processing

Our physiological state has a powerful influence on nervous system function at all levels of processing. The time of day, feeding status and previous experience are all examples of physiological contexts that alter whether, and in what manner, animals respond to incoming information. One mechanism by which the nervous system alters its own activity to cope with changes in physiological context is via neuromodulation, the alteration of neuron response properties without directly inducing excitation or inhibition. By studying the physiological consequences of neuromodulation on olfactory processing in the antennal lobe (the first synapse of the insect olfactory system), my goal is to identify mechanisms implemented by the nervous system to account for physiological context.


Evolution of the Insect Brain

The explosion of insect diversity over evolutionary time has provided a laboratory in which natural selection has implemented manipulations for us. We can use comparative neuroanatomy to determine which traits represent principles of brain function and which traits represent adaptations necessary for survival in a specific environment or to take advantage of a particular resource. By comparing neuroanatomical features of the brain across insect taxa, my goal is to reveal traits that represent fundamental characteristics of the nervous system as well as adaptations that underlie the staggering behavioral complexity of insects.


Lab Personnel

Jing Wang

Jing Wang
Research Technician
2013 MSc Biomedical Engineering and Bioengineering, Syracuse University
2009 BSc Biology, Wuhan University




Ayad Auda

Ayad Auda
Graduate Student
2010 BSc, Pharmacy and Pharmaceutical Chemistry, University of Aleppo




Kristyn Lizbinski

Kristyn Lizbinski
Graduate Student
2013 BS, Neuroscience and Philosophy, University of Scranton




Kaylynn Coates

Kaylynn Coates
Graduate Student
2012 BSc, Biology, Westminster College





Tyler Sizemore

Tyler Sizemore
Graduate Student
2014 BSc, Biology, West Virginia University





Cory Pittman

Cory Pittman
Undergraduate Researcher






Sarah Michaels

Sarah Michaels
Undergraduate Researcher





Cole Michael

Cole Michael
Undergraduate Researcher





Rachel Montgomery

Rachel Montgomery
Undergraduate Researcher





Former Lab Members
Sarah Freeman - Research Technician in lab of Dr. Sergyi Yakovenko at WVU
Aditya Kesari - Attending WVU
Lukas Meadows - Attending WVU Medical School
Jackie Metheny - Research Associate at Nationwide Children's Hospital
Stephen Sinclair - Attending WVU Medical School
Sidney Sisson - Attending WVU Medical School


Publications

[2017]

  • Chapman PD, Bradley SP, Haught EJ, Riggs KE, Haffar MM, Daly KC, Dacks AM. (2017) Co-option of a motor-to-sensory histaminergic circuit correlates with insect flight biomechanics. Proc Biol Sci, 284(1859). pii: 20170339. PMCID: PMC5543211
  • Coates KE, Majot AT, Zhang X, Michael CT, Spitzer SL, Gaudry Q, Dacks AM. (2017) Identified serotonergic modulatory neurons have heterogeneous synaptic connectivity within the olfactory system of Drosophila. J Neurosci, 37(31): 7318-7331. PMCID: PMC5546105[available on 2018-02-02]

[2016]

  • Sizemore TR, Dacks AM. (2016) Serotonergic modulation differentially targets distinct network elements within the antennal lobe of Drosophila melanogaster. Sci Rep, 6:37119. PMCID: PMC5109230
  • Cropper EC, Dacks AM, Weiss KR. (2016) Consequences of degeneracy in network function. Curr Opin Neurobiol, 41: 62-67. PMCID: PMC5123929 [available on 2017-12-01]
  • Bradley SP, Chapman PD, Lizbinski KM, Daly KC, Dacks AM. (2016) A flight sensory-motor to olfactory processing circuit in the moth Manduca sexta. Front Neural Circuits, 10:5. PMCID: PMC4754697
  • Ott BM, Dacks AM, Ryan KJ, Rio RV. (2016) A tale of transmission: Aeromonas veronii activity within leech-exuded mucus. Appl Environ Microbiol, 82(9): 2644-55. PMCID: PMC4836430

[2015]

  • Lizbinski KL, Metheny JD, Bradley SP, Kesari A,  Dacks AM. (2016)  The anatomical basis for modulatory convergence in the antennal lobe of Manduca sextaThe Journal of Comparative Neurology, 524(9): 1859-75. PMCID: PMC4833642

[2014]

  • Ott B, Cruciger M,  Dacks AM, Rio RV.  (2014)  Hitchhiking of host biology by beneficial symbionts enhances transmissionScientific Reports. 4:5825.  PMID:25059557

[2013]

  • Dacks AM, Reale V, Pi Y, Zhang W, Dacks JB, Nighorn AJ, Evans PD. (2013)  A characterization of the Manduca sexta serotonin receptors in the context of olfactory neuromodulation.   PLoS One. 8(7): e69422. doi:10.1371/journal.pone.0069422.
  • Dacks AM, Weiss KR. (2013)  Release of a single neurotransmitter from an identified interneuron coherently affects motor output on multiple timescales .   The Journal of Neurophysiology. 109:2327-2334. (Cover Article)   PMID:23407357
  • Dacks AM, Weiss KR. (2013)  Latent modulation: A basis for non-disruptive promotion of two incompatible behaviors by a single network stateThe Journal of Neuroscience. 33:3786-3798.  PMID:23447591

[2012]

  • Dacks AM, Siniscalchi MJ, Weiss KR. (2012)  Removal of default-state associated inhibition during repetition priming improves response articulation The Journal of Neuroscience. 32:17740-17752.  PMID:23223294
  • Dacks AM, Riffell JA, Martin JP, Gage SL, Nighorn AJ. (2012)  Olfactory modulation by dopamine in the context of aversive learningThe Journal of Neurophysiology. 108(2):539-50. (Cover Article)  PMID:22552185

[2011]

  • Martin JP, Beyerlein A,  Dacks AM, Riffell JA, Lei H, Hildebrand JG. (2011)  The neurobiology of insect olfaction: sensory processing in a comparative contextProgress in Neurobiology. 95:427–447.  PMID:21963552
  • Reisenman CE,  Dacks AM, Hildebrand JG. (2011)  Local interneuron diversity in the primary olfactory center of the moth  Manduca sexta .   The Journal of Comparative Physiology A. 197(6):653-65.  PMID:21286727
  • Dacks AM, Nighorn AJ. (2011)  TheoOrganization of the antennal lobe correlates not only with phylogenetic relationship, but also life history: A basal hymenopteran as exemplarChemical Senses. 36(2):209-20. (Cover Article)  PMID:21059697