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Gregory Konat, PhD/LM, MS

Professor

Gregory Konat, PhD/LM, MS

304.293.0594

My research interests are primarily focused on the immune-to-brain communication. In particular, the research objective of my laboratory is to elucidate mechanisms by which inflammatory episodes in the periphery alter brain function.

Affiliations

Physiology, Pharmacology, &  Neuroscience; Blanchette Rockefeller Neurosciences Institute

Graduate Training

University of Southern Denmark, Biochemistry

Research Topics

The immune system and the brain maintain intricate communication that plays an important role in both health and disease. For example, epidemiological evidence indicates that peripheral viral infections are comorbid factors in seizures. The putative mechanisms entail pathways by which inflammatory signals are relayed to the brain and lower seizure threshold. However, these pathways have not been defined. We have developed a preclinical murine model in which the peritoneal injection of a viral mimetic, polyinosinic-polycytidylic acid (PIC) robustly increases susceptibility to kainic acid (KA)-induced seizures. Subsequent studies have indicated that the principal mechanism entails dysregulation of glutamate homeostasis in hippocampal astrocytes and that this dysregulation is mediated by the activation of endogenous complement pathways.


Lab Personnel

Tiffany Petrisko
Graduate Student
304.293.6621
tjpetrisko@mix.wvu.edu

Brent Lally
Research Assistant
304.293.1209
blally@hsc.wvu.edu


Collaborators

Ariel Agmon, PhD
WVU Department of Neurobiology
304.293.0602
aagmon@hsc.wvu.edu

Miranda Reed, PhD
Drug Discovery and Development
Auburn University
334.844.7401
reedmir@auburn.edu

Bernard Schreurs, PhD
WVU Department of Physiology
304.293.0497
bschreurs@hsc.wvu.edu

James Simpkins, PhD
WVU Department of Physiology & Pharmacology
jwsimpkins@hsc.wvu.edu

James P. O'Callaghan, PhD
Toxicology & Molecular Biology Branch, CDC/NIOSH
304.285.6079
jdo5@cdc.gov

Diane B. Miller, PhD
Toxicology & Molecular Biology Branch, CDC/NIOSH
304.285.6079
dum6@cdc.gov

Halina Offner, Dr. MED
Department of Neurology
Oregon Health and Science University, Portland
503.721.7893
offnerva@ohsu.edu

Adrienne Salm, PhD
WVU Department of Neurobiology
304.293.2435
asalm@hsc.wvu.edu

Arthur Vandenbark, PhD
Department of Molecular Microbiology & Immunology
Oregon Health and Science University
503.273.5113
vandenba@ohsu.edu

Hanting Zhang, MD, PhD
WVU Department of Behavioral Medicine & Psychiatry
304.293.5850
hzhang@hsc.wvu.edu


Recent Publications

[2016]

  • Hunsberger, H.C., Wang, D., Konat, G., Reed, M.N. (2016) Peripherally restricted viral challenge elevates extracellular glutamate and enhances synaptic transmission in the hippocampus. J. Neurochem. (in press).

  • Bhardwaj, R., Hobbs, G., Wissam, G., Konat, G., Bradford, W., Abnash, J., (2016) Acute effects of diets rich in almonds and walnuts on endothelial function. Scand. Cardiovasc. J. (in revision).

  • Konat, G. (2016) Cerebral response to peripheral challenge with a viral mimetic. Neuroche. Res. 41:144-155.

[2015]

  • Salm, A.K., Lally, B.E., Borysiewicz, E., Fil, D. and Konat, G.W. (2015) Analysis of extinction to attenuated tones in prenatally stressed and non-stressed offspring following fear conditioning. Physiol. Behav. 139:157-166.

  • Michalovicz, L.T., Lally, B. and Konat, G.W. (2015) Peripheral challenge with a viral mimic upregulates expression of the complement genes in the hippocampus. J. Neuroimmunol. 285:137-142.

[2014]

  • Michalovicz, L.T. and Konat, G.W. (2014) Peripherally restricted acute phase response to a viral mimic alters hippocampal gene expression. Met. Brain Dis. 29:75-86.

[2013]

  • Borysiewicz E, Doppalapudi S, Kirschman LT, Konat GW. (2013) TLR3 ligation protects human astrocytes against oxidative stress. J Neuroimmunol 255:54.9.

[2011]

  • Konat GW, Lally BE, Toth AA, Salm AK. Peripheral immune challenge with viral mimic during early postnatal period robustly enhances anxiety-like behavior in young adult rats. Met Brain Dis (2011 Sep) 26(3):237-40.
  •            
  • Fil D, Borysiewicz E, Konat GW. A broad upregulation of cerebral chemokine genes by peripherally-generated inflammatory mediators. Metab Brain Dis. (2011), 26(1):49-59.
  •            
  • Kirschman LT, Fil D, Borysiewicz E, Konat GW. Peripheral immune challenge with dsRNA enhances kainic acid-induced status epilepticus. Metab Brain Dis. (2011), 26(1):91-3.

More publications