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Peter H. Mathers, PhD

Associate Professor

 Peter Mathers

304-293-0271

Affiliations

Otolaryngology/Head & Neck Surgery; Ophthalmology; Biochemistry; Blanchette Rockefeller Neurosciences Institute 

Graduate Training

PhD, Molecular Biology, California Institute of Technology

Fellowship

Developmental Biology, National Institutes of Health
Developmental Biology, Food & Drug Administration

Research Interests

My laboratory works on the molecular genetics of two developmental sensory systems: the eye and the ear. We seek to understand the genes required for the formation of early retinal tissue during eye formation and in the development of specific relay centers in the auditory brainstem that are critical for hearing. Using transgenic and targeted deletion (knockout) mouse models, the lab is studying the function of specific transcription factors in regulating developmental gene expression patterns and deciding the fate of these particular tissues. These studies use molecular, genetic, and biochemical techniques—along with fluorescent and histochemical imaging—to understand how genetic mutations affect the formation of sensory organs. We have developed genetic models that allow us to delete a gene at selected times, allowing a detailed analysis of that gene’s function at various stages of development. We have also used mutational screens in patients to identify a cause for anophthalmia, a condition where patients are born without eyes. Our current work with stem cells is aimed at repairing damaged sensory tissue through regeneration. 

Research Topics

My laboratory works on the molecular genetics of two developmental sensory systems: the eye and the ear. We seek to understand the genes required for the formation of early retinal tissue during eye formation and in the development of specific relay centers in the auditory brainstem that are critical for hearing. Using transgenic and targeted deletion (knockout) mouse models, the lab is studying the function of specific transcription factors in regulating developmental gene expression patterns and deciding the fate of these particular tissues. These studies use molecular, genetic, and biochemical techniques—along with fluorescent and histochemical imaging—to understand how genetic mutations affect the formation of sensory organs. We have developed genetic models that allow us to delete a gene at selected times, allowing a detailed analysis of that gene’s function at various stages of development. We have also used mutational screens in patients to identify a cause for anophthalmia, a condition where patients are born without eyes. Our current work with stem cells is aimed at repairing damaged sensory tissue through regeneration.

Lab Personnel

Dennis Cole
Research Assistant 
304-293-0273
dcole@hsc.wvu.edu

Helen Rodgers
Graduate Student
304-293-0273
hrodgers@mix.wvu.edu

Publications

[2016]

[2013]

[2012]

[2010]

[2009]
  • Hoffpauir BK, Marrs GS, Mathers PH, Spirou GA. Does the brain connect before the periphery can direct? A comparison of three sensory systems in miceBrain Res. (2009),1277:115-29.
  • Fancy T, Mathers PH, Ramadan HH . Otitis media with effusion: a possible role for Helicobacter pylori?  Otolaryngol Head Neck Surg. (2009),140(2):256-8.
[2007]
  • Howell DM, Morgan WJ, Jarjour AA, Spirou GA, Berrebi AS, Kennedy TE, Mathers PH. Molecular guidance cues necessary for axon pathfinding from the ventral cochlear nucleus. J ournal of Comparative Neurology (2007), 504(5):533-549.
[2006]
  • Hoffpauir BK, Grimes JL, Mathers PH, Spirou GA. Synaptogenesis of the calyx of Held: rapid onset of function and one-to-one morphological innervation. Journal of Neuroscience (2006), 26(20):5511-23.
  • Ma Y, Hu H, Berrebi AS, Mathers PH, Agmon A. Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice. Journal of Neuroscience (2006), 26(19):5069-5082.
  • R ao AK, Mathers PH, Ramadan HH. Detection of fungi in the sinus mucosa using polymerase chain reactionOtolaryngology—Head and Neck Surgery( 2006), 134(4):581-585.