Our lab studies the causes and potential treatment for Alzheimer’s disease (AD) and stroke in animal models and in human subjects. We are trying to understand the cause of brain damage from AD stroke and to develop treatments based on our understanding of causes.
Physiology, Pharmacology, & Neuroscience; Blanchette Rockefeller Neurosciences Institute
PhD, Physiology, Michigan State University; MS, Biology, University of Toledo
Our lab studies the causes and potential treatment for Alzheimer’s disease (AD) and stroke in animal models and in human subjects. We are trying to understand the cause of brain damage from AD stroke and to develop treatments based on our understanding of causes. We use rats to induce stroke damage and a variety of techniques, including molecular biology, behavioral assessment and drug interventions to determine the causes and potential treatment for stroke damage. Our work also involves the use of transgenic mouse models, primarily for modeling AD. West Virginia has one of the highest incidences of stroke in the nation and currently therapies to limit stoke damage are limited. Our lab therefore is searching for novel treatments that can limit the damage and/or improve recovery from stroke.
Dana Foundation Blog: Dr. Simpkins on Stroke - http://danablog.org/2014/05/29/james-simpkins-on-stroke/
Xuefang Ren, MD
Director, Experimental Stroke Core
Elizabeth Engler-Chiurazzi, PhD
Stephanie Rellick, PhD
Danielle Doll, PhD
Saumyendra Sarkar, PhD
Heng Hu, MD
Sujung Jun, PhD
Sara Lewis, MS
Former Undergraduate Students
Biology Undergraduate Student
- Sun J, Ren X, Qi W, Yuan D, Simpkins JW. Geissoschizine methyl ether protects oxidative stress-mediated cytotoxicity in neurons through the 'Neuronal Warburg Effect. ' J Ethnopharmacol (2016) 187: 249-58. PMCID: PMC4887292
- Engler-Chiurazzi EB, Stapleton PA, Stalnaker JJ, Ren X, Hu H, Nurkiewicz TR, McBride CR, Yi J, Engels K, Simpkins JW. Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition. J Toxicol Environ Health A (2016) 79(11): 447-52. [Epub 2016 Apr 19]
- Strong R, Miller Ra, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Marinez PA, McCord JM, Miller BF, Müller M, Nelson JD, Ndukum J, Rainger GE, RIchardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Longer lifespan in mile mice treated with a weakly estrogenic agonist, and antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell (2016).
- Sarker S, Jun S, Rellick S, Quintana DD, Cavendish JZ, Simpkins JW. Expression of MircroRNA-34a in Alzheimer's Disease Brain Targets Genes Linked to Synaptic Plasticity, Energy Metabolism, and Resting State Network Activity. Brain Res (2016) pii:S0006-8993(16)30382-1.
- Petrone AB, O'Connell GC, Regier MD, Chantler PD, Simpkins JW, Barr TL. The Role of Arginase 1 in Post-Stroke Immunosuppression and Ischemic Stroke Severity. Transl Stroke Res (2016) 7(2): 103-10. PMCID: PMC4770061
- Sun J, Hu H, Ren X, Simpkins JW. Tert-butylhydroquinone compromises survival in murine experimental stroke. Neurotoxicol Teratol (2016) 54: 15-21. PMCID: PMC4789102
- Engler-Chiurazzi EB, Singh M, Simpkins JW. From the 90's to know: A brief historical perspective on more than two decades of estrogen neuroprotection. Brain Res (2016) 1633: 96-100. PMCID: PMC4762740
- Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW. Estrogens as neuroprotectants: Estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol (2016) pii: S0301-0082(15)30063-0.
- Bukeirat M, Sarkar SN, Hu H, Quintana DD, Simpkins JW, Ren X. MiR-34a regulates blood-brain barrier permeability and mitochondrial function by targeting cytochrome c. J Cereb Blood Flow Metab (2016) 36(2): 387-92. PMCID: PMC4759667
- Hu H, Doll DN, Sun J, Lewis SE, Wimsatt JH, Kessler MJ, Simpkins JW, Ren X. Mitochondrial impairment in cerebrovascular endothelial cells is involved in the correlation between body temperature and stroke severity. Aging Dis (2016) 7(1): 14-27. PMCID: PMC4723230
- Moses BS, Slone WL, Thomas P, Evans R, Piktel D, Angel PM, Walsh CM, Cantrell PS, Rellick SL, Martin KH, Simpkins JW, Gibson LF. Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype. Exp Hematol (2016) 44(1): 50-9.e1-2. PMCID: PMC4684957
More publications: http://www.ncbi.nlm.nih.gov/pubmed