AffiliationsBehavioral Medicine & Psychiatry; Physiology, Pharmacology, & Neuroscience; Blanchette Rockefeller Neurosciences Institute
Bejing Institute of Pharmacology & Toxicology, Beijing,China; Southern Medical University (the former First Military Medical University), Guangzhou, China, BS, MD; Beijing Institute of Pharmacology and Toxicology, the Academy of Military Medical Sciences, China, M.S., Ph.D.
Pharmacology, Louisiana State University Health Sciences Center Pharmacology, University of Tennessee Health Science Center
My major research interests focus on behavioral and cellular signaling
mechanisms in treatment of neurodegenerative and neuropsychiatric disorders.Specifically, I am interested in exploring the roles of cyclic nucleotide (cAMP/cGMP) signaling in the mediation of depression, anxiety, alcohol dependence, drug abuse, and memory loss associated with neurodegenerative disorders such as Alzheimer’s disease. Techniques include various animal behavioral tests (e.g., radial arm-maze, water-maze, passive avoidance, and object recognition for memory; DRL schedule, forced-swim, and tail-suspension for depression; elevated-plus maze, holeboard, and light-dark transition for anxiety; alcohol drinking behavior, self-administration, and righting reflex for alcohol and/or drug dependence), small animal surgeries for brain microinfusions, enzyme assays, immunoblotting, immunohistochemistry, RNAi gene silencing (shRNAs, CRISPR-Cas9), optogenetics, etc. Our goals are to develop ideal treatments for neurodegenerative and neuropsychiatric disorders, drug abuse and dependence and elucidate the mechanisms whereby intracellular signaling mediates these disorders.
Lab PersonnelXiujie Liang
Research Scholar/Graduate Student
Wangxin Zhang, M.D.
Hong Q, Ma ZC, Huang H, Wang YG, Tan HL, Xiao CR, Liang QD, Zhang HT*, Gao Y*. Antithrombotic activities of ferulic acid via intracellular cyclic nucleotide signaling. Eur J Pharmacol. 2016, 777:1-8. PMID: 26948317
Jiang YM, Li XJ, Meng ZZ, Liu YY, Zhao HB, Li N, Yan ZY, Ma QY, Zhang HT, Chen JX. Effects of Xiaoyao-san on Stress-induced Anxiety-like Behavior in rats: involvement of CRF1 Receptor. Evid Based Complement Alternat Med. Epub 2016 Mar 2. PMID: 27042185
Chen Z, Yang X, Xu Y*, Zhang HT*. Antidepressant drugs and phosphodiesterases. In: Melatonin and neuroprotective agents in neuropsychiatric disorders. Srinivasan V, Lopez- Munoz F, De Berardis D, Gonzalez CA, Kato TA, eds. Springer Publishing, New York, NY, USA, 2016, in press. Book chapter.
Wang ZZ, Yang WX, Zhang Y, Zhao N, Zhang YZ, Liu YQ, Xu Y, Wilson SP, O'Donnell JM, Zhang HT, and Li YF. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. Scientific Reports. 2015, Jul 10; 5:11332. PMID: 26161529 (PMCID: PMC4498385)
Pang C, Cao L, Wu F, Wang L, Wang G, Yu Y, Zhang M, Chen L, Wang W, Chen L, Zhu J, Pan J, Zhang H, Xu Y, Ding L. The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis. Neuropharmacology. 2015, 97:447-56. PMID: 25937213
Xu Y, Pan JC, Sun J, Ding LS, Ruan L, Reed M, Yu XF, Klabnik J, Lin D, Li JX, Chen L, Zhang C, Zhang HT, O'Donnell JM. Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress. Neurobiology of Aging. 2015, 36:955-970. PMID: 25442113
Zhang HT. New insights into phosphodiesterases (PDEs) from CNS functions and diseases. Curr Pharm Des. 2015, 21:271-273. Review. PMID: 25426634
- Wang ZZ, Zhang Y, Zhang HT, Li YF. Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases. Curr Pharm Des. 2015, 21:303-316. Review. PMID: 25159069
Zhang C, Yu Y, Ruan L, Wang C, Klabnik J, Lueptow L, Zhang HT, O’Donnell JM, Xu Y. The roles of phosphodiesterase 2 in the central nervous and peripheral systems. Curr Pharm Des. 2015, 21:274-290. Review. PMID: 25159070
Wen RT, Feng WY, Liang JH*, Zhang HT*. Role of Phosphodiesterase 4-mediated cyclic AMP signaling in pharmacotherapy for substance dependence. Curr Pharm Des. 2015, 21:355-364. Review. PMID: 25159074
Hansen RT III, Zhang HT. Phosphodiesterase-4 modulation as a potential therapeutic for cognitive loss in pathological and non-pathological aging: Possibilities and Pitfalls. Curr Pharm Des. 2015, 21:291-302. Review. PMID: 25159075